The traditional Clinical Trial Management System (CTMS) was designed to view and keep data within the walls of either the sponsor, the Clinical Research Organization (CRO) or data vendors. Historically a CTMS was able to sufficiently handle clinical trial data as there were fewer data sources. However, the proliferation of data sources and the rise of outsourced trials changed how CTMS is defined and called into question whether they are fit for purpose in today’s world.